In doses of 50 mg/day or less (typical doses range from 25-50 mgs/day for men although as high as 100 mgs/day is reported) there does not appear to be significant disruption of the HPTA or hypothalamic/pituitary/testicular axis.
Dianoxyl use by women, even in low doses, can result in significant virilization and is therefore not usually recommended.
Side effects for methandienone are certainly dose related with the frequency of occurrence and severity increasing correspondingly.
Bloating, gynecomastia, acne, hair-loss, and elevated liver enzymes are all possible side effects along with disruption of the HPTA and HDL/LDL issues.
Once again, keeping the dose to a maximum of 50 mg/day for 6-8 weeks should limit the extent of side-effects experienced from this hormone.